Cortex API Documentation

Governed biomedical reasoning service. Submit cancer research queries, receive ranked hypotheses as Research Objects.

Getting Started

1. Sign Up

Register with your email. You'll receive a tenant_id and start on the Basic plan.

2. Get Access Token

curl -X POST https://cognito-idp.us-east-1.amazonaws.com/ \
  -H "Content-Type: application/x-amz-json-1.1" \
  -H "X-Amz-Target: AWSCognitoIdentityProviderService.InitiateAuth" \
  -d '{
    "AuthFlow": "USER_PASSWORD_AUTH",
    "ClientId": "4avt1d5kblqrprcov4vo14c2hl",
    "AuthParameters": {"USERNAME": "you@email.com", "PASSWORD": "YourPass1"}
  }'

Save the IdToken. Use it as Authorization: Bearer TOKEN in all calls.

3. Submit a Job

curl -X POST https://lkk5jdgj77.execute-api.us-east-1.amazonaws.com/prod/jobs \
  -H "Authorization: Bearer TOKEN" \
  -H "Content-Type: application/json" \
  -d '{"query": "Find pancreatic cancer biomarkers linked to KRAS therapy resistance", "cancer_type": "pancreatic"}'

{"job_id": "CX-A1B2C3D4", "status": "QUEUED", "message": "Poll GET /jobs/CX-A1B2C3D4 for result."}

4. Get Result

curl https://lkk5jdgj77.execute-api.us-east-1.amazonaws.com/prod/jobs/CX-A1B2C3D4 \
  -H "Authorization: Bearer TOKEN"

API Reference

POST /prod/jobs

GET /prod/jobs

List your recent jobs (last 20).

GET /prod/jobs/{id}

Get full result: Research Object, hypotheses, scores, validation plan.

Example Queries

"Find pancreatic cancer biomarkers linked to KRAS therapy resistance"
"Find prostate cancer biomarkers associated with castration resistance"
"Find cross-omics biomarkers in TCGA-PRAD that predict drug response"
"Find biomarkers shared between pancreatic and prostate treatment resistance"
"Run Cortex on CRYZ, PRR36, DNAH5 in prostate cancer"
"Monitor ATP1A4 as a novel PDAC target"

What You Get Back

Pricing

Supported Cancers

Security

• Cognito JWT authentication
• Tenant isolation — your data never visible to others
• Authority ceiling — Cortex cannot expand governance decisions
• Ledger-hashed provenance from query to Research Object
• No patient data crosses governance boundary

Cortex API v1 | MindNetQ Cortex | MindNetQ Governed | 2026