The closed-loop intelligence system that discovers, generates, validates, and learns — without human intervention.
| Component | Role | Input | Output | Status |
|---|---|---|---|---|
| Physician-rs | Target Discovery | Omics + DepMap + literature | Novel cancer targets | LIVE |
| CortexQ Gen v4 | Molecule Generation | Pathway + pocket + class + capsules | Drug-like SELFIES (100% valid) | LIVE |
| NPEAD v5.2 | Authority Scoring | 18 dims + outcomes | Advance / Hold / Reject | LIVE |
| Knowledge Capsules | Brain Compression | 15 brain signals per cancer | Decision-ready claims → generator | NEW |
| Rejection Sampling | Self-Improvement | 1000 generated → 50 docked | Top 10 → fine-tune model | NIGHTLY |
| NPEAD Phase 9 | Weight Learning | Gate outcomes on brain-bus | Adjusted gate thresholds | NIGHTLY |
| Evidence Chain | Governance | Every decision | Hash-linked audit trail | LIVE |
| Cortex Master v7 | Strategic Brain | 53 dims (all signals) | Trust + Strategy + Interest | LIVE |