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🧬 SLC25A37 — Discovery Report

📄 Autonomous discovery by Cortex · 2026-05-22

Gene	SLC25A37
Full Name	Solute Carrier Family 25 Member 37 (Mitoferrin-1)
Target Protein	SLC25A37_protein
Cancer Type	Prostate / Pancreatic
Grade	A+
Priority	HIGH
Stage	lead_candidate
Novelty	FIRST-IN-CLASS (0 ChEMBL)

🧬 BioBrain ⚖️ Decisions

Scientific Hypothesis

"Mitoferrin-1 imports iron into mitochondria fueling cancer cell oxidative metabolism. Blocking it starves tumor mitochondria of iron, collapsing electron transport."

Mechanism of Action

Pathway: SLC25A37 → mitochondrial iron import → ROS → tumor survival

Clinical Angle: Metabolic vulnerability: iron-dependent mitochondrial respiration in PRAD/PAAD

Docking Results

Metric	Value
Best Vina Score	-9.5 kcal/mol
Best Molecule (SMILES)	`O=C(Cc1ccc2ncccc2c1)Nc1ccc(C(=O)O)c(F)c1`
Molecular Weight	324.31100000000004 Da
QED / DCSAL	0.707
Molecules Tested	10
Docking Method	smina (real GPU, g4dn.xlarge)
Receptor Source	AlphaFold v4

5-Dimension Scoring

🎯 Binding: 0.95 🔬 Pathway: 0.89 💡 Innovation: 0.95 💊 Therapy: 0.89 ⭐ Novelty: 1.0 🧬 BioBrain ⚖️ Decisions

Total Score: —

CDx / Diagnostic Potential

Prognostic: high expression correlates with aggressive disease + iron metabolism dependency. CDx: predict response to iron-targeting therapy.

Governance

PQM Status	ISSUED
QCM Trust	1.0
Ledger Logged	✅ SHA-256 hash chain
Evidence ID	RO-SLC25A37
Authority	marcus_60 (sole override)

Conclusion

SLC25A37 is a FIRST-IN-CLASS (0 ChEMBL) target with A+ grade binding affinity (-9.5 kcal/mol). The mechanistic hypothesis (SLC25A37 → mitochondrial iron import → ROS → tumor survival) provides a clear therapeutic rationale for Prostate / Pancreatic. Metabolic vulnerability: iron-dependent mitochondrial respiration in PRAD/PAAD. Recommended for wet lab validation.

MindNetQ Inc. — Governed Intelligence for Precision Medicine
Report generated by Cortex autonomous discovery pipeline. All decisions ledger-hashed.